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  • In utero and lactational exposures to …

    However, whether in utero and lactational exposures of DEHP affect Leydig cells has not been well established. In the present study, the effects of DEHP exposures on fetal Leydig cells (FLCs) and adult Leydig cells (ALCs) were assessed. Pregnant dams of Long-Evans rats were treated with 0, 10, and 750 mg/kg body weight DEHP from Gestational Day 12.5 to Postnatal Day (PND) 21.5. Fetal Leydig ...

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  • Effects of and Lactational TCDD Exposure on Bone ...

    lactational exposure was required to cause the bone defects. Most of the defects were recovered at the age of one year. The results indicate that dioxins affect developing bone by interfering with bone growth and mechanical strength and that the effects are mainly reversible. The dioxin resistance alleles, Ahr hw and B hw increase the resistance to these defects. Key words dioxin, development ...

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  • Lactational exposure to environmentally …

    01.04.2019· BaP lactational exposure has no effect on short-time memory of offspring. Y maze test was used to evaluate short-term memory of the animals after BaP (10 μg/kg) lactational exposure. The times (right panel) or the percent (left panel) of alternation triplet in three arms of Y maze were calculated. (A) All offspring were analyzed. (B) Male and female offspring were analyzed separately. The ...

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  • Effects of in utero- lactational- and direct …

    The results of this study indicate that in utero-, lactational- and direct exposure to mixture of EDCs found in a malaria area, at the levels used here, has negative impacts on normal genital development after in utero exposure and on spermatogenesis in adulthood after combined prenatal, lactational and postnatal exposure. These findings raise concerns to EDC exposures to mothers living in ...

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  • Lactational exposure to short-chain chlorinated …

    Lactational exposure to short-chain chlorinated paraffins in China, Korea, and Japan. Chemosphere. 2017; 173:43-48 (ISSN: 1879-1298) Cao Y; Harada KH; Hitomi T; Niisoe T; Wang P; Shi Y; Yang HR; Takasuga T; Koizumi A. To investigate short-chain chlorinated paraffin (SCCP) levels in human breast milk, pooled breast milk samples (BMSs) collected between 2007 and 2010 from Chinese (Beijing, n ...

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  • Lactational exposure to polychlorinated …

    Lactational exposure up to 12 months of age was estimated as the product of chemical concentrations and the duration of breast feeding. The infant's weight and length were recorded from the medical record for each routine paediatric well‐child visit in the first 12 months. Women–child pairs who breast fed for 6 months or longer and returned the growth card n = 210) were included in the ...

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  • Lactational Exposure to Polybrominated …

    Effects of short-term in vivo exposure to polybrominated diphenyl ethers on thyroid hormones and hepatic enzyme activities in weanling rats. Toxicol Sci 61:76-82 11294977. Crossref, Medline, Google Scholar; Zhou T, Taylor MM, DeVito MJ, Crofton KM. 2002. Developmental exposure to brominated diphenyl ethers results in thyroid hormone disruption.

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  • Lactational exposure to polychlorinated …

    Lactational exposure up to 12 months of age was estimated as the product of chemical concentrations and the duration of breast feeding. The infant's weight and length were recorded from the medical record for each routine paediatric well‐child visit in the first 12 months. Women–child pairs who breast fed for 6 months or longer and returned the growth card n = 210) were included in the ...

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  • Lactational exposure to short-chain chlorinated …

    01.04.2017· Lactational exposure to short-chain chlorinated paraffins in China, Korea, and Japan Author links open overlay panel Yang Cao a b Kouji H. Harada a Toshiaki Hitomi b Tamon Niisoe a Peiyu Wang c Yuhui Shi c Hye-Ran Yang d Takumi Takasuga e Akio Koizumi a

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  • Rat Thyroid Hyperplasia Induced by Gestational …

    Effects of gestational and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on thyroid function of offspring were investigated in the rat. Pregnant Holtzman rats, TCDD-sensitive strain, were given a single oral dose of 200 ng or 800 ng TCDD/kg on gestational day 15. Parameters related to the thyroid functions were examined on postnatal days (PNDs) 21 and 49. Serum T 4 levels ...

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  • Lactational exposure to short-chain chlorinated …

    Lactational exposure to short-chain chlorinated paraffins in China, Korea, and Japan. Cao Y(1), Harada KH(2), Hitomi T(3), Niisoe T(2), Wang P(4), Shi Y(4), Yang HR(5), Takasuga T(6), Koizumi A(7). Author information: (1)Department of Health and Environmental Sciences, Kyoto University Graduate School of Medicine, Yoshida, Kyoto, 606-8501, Japan; Department of Preventive Medicine, St. …

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  • Effects of Short-Chain Chlorinated Paraffins …

    Dietary exposure to short- and medium-chain chlorinated paraffins in meat and meat products from 20 provinces of China. Environmental Pollution 2018, 233, 439-445. DOI: 10.1016/j.envpol.2017.10.022. Huijuan Li, Jianjie Fu, Wenxiao Pan, Pu Wang, Yingming Li, Qinghua Zhang, Yawei Wang, Aiqian Zhang, Yong Liang, Guibin Jiang. Environmental behaviour of short-chain chlorinated paraffins in aquatic ...

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  • [PDF] Effects of uterine and lactational exposure …

    Di-(2-ethylhexyl) phthalate (DEHP) is an environmental endocrine disrupter. Currently, little is known about neurodevelopmental toxicity of DEHP in wildlife and humans. The present study investigated the effects of DEHP, focusing on the changes in the behavior of offspring mice at the ages of 6 and 12w, respectively, following utero and lactational exposure to DEHP (10, 50, and 200mg/kg/d ...

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  • Lactational Exposure to Polychlorinated …

    Lactational exposure of these chemicals was estimated by the product of chemical concentrations and the duration of breast-feeding. Infant development at 12 months of age was measured by the Mullen Scales of Early Learning (n = 231) and the Short Form: Level I (infant) of the MacArthur–Bates Communicative Development Indices (n = 218). Results . No consistent associations were observed ...

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  • Gestational and lactational exposure to …

    Overall, these results indicate that prenatal and lactational exposure to gossypol alters the expression of many genes involved in testicular function. Although several studies have shown the toxicity of gossypol in male reproduction, the precise mechanisms of gossypol action in the testicles have not yet been fully elucidated. Of special interest, spermatogenesis (GO:0007283) was identified ...

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