chlorinated paraffins effect of some microsomal enzyme

  • Effects of Short-Term in Vivo Exposure to Polybrominated ...

    May 01, 2001· where y is the response; x is the dose; e 0 is the estimated background response level; e max is the maximal increase or decrease from background; b is the ED 50; and n is the shape parameter. The benchmark effect levels were set at 20% decreases for the thyroid hormone data and 50% increases for the liver enzyme data. The BMDs were calculated from the Hill fits to the data.

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  • Alkanes, C14-17, chloro - Registration Dossier - ECHA

    Effects of chlorinated paraffins on some drug-metabolising enzymes in rat liver and in the Ames test. Adv. Exp. Med. Biol. A136: 821-828 (cited in EU, 2008). Meijer J and DePierre J (1987). Hepatic levels of cytosolic, microsomal and ‘mitochondrial’ expoxide hydrolases and other drug-metabolising enzymes after treatment of mice with various ...

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  • Chlorinated paraffins [MAK Value Documentation, 1996 ...

    Jan 31, 2012· The no effect level determined in another study (Wyatt et al. 1991 a) for effects on the cyanide-insensitive palmitoyl-CoA oxidase activity was 184 mg/kg body weight and day in the rat and 180 mg/kg body weight and day in the mouse for chlorinated paraffins C 10–13 with 58 % chlorine, 600 mg/kg body weight and day in the rat and 120 mg/kg ...

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  • Characterization and cDNA cloning of a clofibrate ...

    Nov 28, 2003· The sEHs were induced by the peroxisome proliferator agents (p‐chlorophenoxyacetic acid, 2,4‐dichlorophenoyacetic acid, clofibrate) [[9, 14, 15]], chlorinated paraffins, and di(2‐ethylhexyl)phthalate []. Some inductions were confirmed to occur at the transcriptional level [[11, 12]]. The induction of mEH in rats is coordinated with the ...

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  • Polybrominated diphenyl ethers (PBDEs), polychlorinated ...

    Aug 15, 2002· B. BrunströmEffects of chlorinated paraffins on liver weight, cytochrome P-450, concentration and microsomal enzyme activities in chick embryos Arch. Toxicol., 57 …

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  • Peroxisome Proliferators: Their Biological and ...

    Jun 27, 2001· Abstract One of the most rapidly developing areas of organelle biology, which has a major involvement in biochemical pharmacology, is the research into the peroxisomal function. There is a large group of compounds that are capable of inducing liver enlargement, proliferation of peroxisomal structures, and induction of peroxisomal and extraperoxisomal fatty acid-oxidizing enzymes …

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  • Aopwiki

    Hood, A. and C.D. Klaassen. (2000a) Differential effects of microsomal enzyme inducers on in vitro thyroxine (T(4)) and triiodothyronine (T(3)) glucuronidation. Toxicol. Sci. 55(1): 78-84. Hood, A. and C.D. Klaassen. (2000b) Effects of microsomal enzyme inducers on outer-ring deiodinase activity toward thyroid hormones in various rat tissues ...

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  • Occurrence of polychlorinated terphenyls (PCTs) in indoor ...

    Nilsen OG, Toftgård R. Effects of polychlorinated terphenyls and paraffins on rat liver microsomal cytochrome P-450 and in vitro metabolic activities. Arch Toxicol. 1981 Mar; 47 (1):1–11. Bitman J, Cecil HC, Harris SJ. Biological effects of polychlorinated biphenyls in rats and quail. Environ Health Perspect. 1972 Apr; 1:145–149.

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  • Metabolism of 1,2‐Dichloroethane‐14C in the Mouse - Yllner ...

    Labelled 1,2‐dichloroethane (3.6 μci/mg), prepared by chlorination of ethylene‐ 14 C, was injected intraperitoneally (0.05–0.17 g/kg) and the elimination of radioactivity was followed for 3 days. Depending on the dose 10–42% was expired unchanged and 12–15% as carbon dioxide. 51–73% of the dose was found in the urine, 0–0.6% in the faeces (contaminated with urine), and 0.6–1.3 ...

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  • Effects of chlorinated paraffins on liver weight ...

    Apr 01, 1985· Sublethal doses of three technical preparations of chlorinated paraffins (CPs) (Cereclor 42 (C22–26, 42% Cl w/w), Cereclor 50LV (C10–13, 49% Cl w/w) and Cereclor 70L (C10–13, 70% Cl w/w)) were injected into the yolks of hens' eggs after 4 days of incubation. The liver weight, the cytochrome P-450 concentration in the liver and the liver microsomal activity of aminopyrine N …

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  • Chlorinated_paraffins | LGC Standards

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  • Chlorinated Hydrocarbons and Ventral Hernia

    Hydrocarbon compounds with one or more of the hydrogens replaced by CHLORINE. | Explore the latest full-text research PDFs, articles, conference papers, preprints and more on CHLORINATED ...

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  • 5 Keys to Improving Thyroid Hormone Conversion ...

    Wyatt I, Coutts CT, Elcombe CR. The effect of chlorinated paraffins on hepatic enzymes and thyroid hormones. Toxicology 1993;77:81-90. van Raaij JA, Kaptein E, Visser TJ, van den Berg KJ. Increased glucuronidation of thyroid hormone in hexachlorobenzene-treated rats. …

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  • Chlorinated paraffins [MAK Value Documentation, 1996 ...

    Jan 31, 2012· The no effect level determined in another study (Wyatt et al. 1991 a) for effects on the cyanide-insensitive palmitoyl-CoA oxidase activity was 184 mg/kg body weight and day in the rat and 180 mg/kg body weight and day in the mouse for chlorinated paraffins C 10–13 with 58 % chlorine, 600 mg/kg body weight and day in the rat and 120 mg/kg ...

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  • Toxicokinetics of short-chain chlorinated paraffins in ...

    Feb 01, 2016· P.O. DarnerudChlorinated paraffins: effect of some microsomal-enzyme inducers and inhibitors on the degradation of 1-14 C-chlorododecanes to 14 CO 2 in mice Acta. Pharmacol.

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